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Histology, Gene and Cell Therapy

Course code:

BM014

Teacher:

Antonia FOLLENZI

SSD:

BIO/17

Degree program:

Course in Medical Biotechnologies

Year:

I

Semester:

II

Credits

5

Hours

30

Comprehensive course:

Regenerative Medicine

Academic year:

2014/2015

 

Course objectives

To become knowledgeable in gene transfer procedures used in gene therapy.
To understand the cell therapy potential in regenerative medicine.

 

Knowledge and skills expectations

The students should be come able to discuss cell and gene therapy published articles and fundamental vectorology used in gene therapy in preclinical studies and clinical trials.

 

Course program

Stem cells, cellular reprogramming and use of these cells in cell therapy protocols in preclinical and potential applications in the clinic.
Isolation, in vitro expansion and preparation of cells for experimental cell therapy.
Vectors used for gene transfer: viral vectors and non-viral. Origin, construction and modification.
Modulation of Expression cassettes: Constitutive and regulated expression. transcriptional or post-transcriptional expression regulation Immune response to vectors and transgenes used in gene transfer.
Concepts of ex vivo and in vivo gene therapy.
Clinical trials using cell and gene therapy strategies of target diseases.

 

Practical training

Group seminar prepared by the students on a chosen topic.

 

Optional activities

None

 

Course materials

Slides and PDF articles

 

Required texbooks / Bibliographic resources

For italians: Lollini, Terapia genica, ZANICHELLI
Animated gene therapy course, Utah University, USA

Journals:
Human Gene Therapy
Gene Therapy
Cancer Gene Therapy
Journal of Gene Medicine
Molecular Therapy
Nature
Science

Databases:
NCBI - MEDLINE, GenBank, Genomi, ecc.
Genetic Modification Clinical Research Information System (GeMCRIS)
Clinicaltrials USA
Wiley clinical trial database

 

Methods of evaluation

Written test including a commentary on a cell and gene therapy paper and an oral discussion on a topic of the course program.

Notice

Notice for the students of the first year of Master in Medical Biotechnologies

  • Internship notice and form are available for download

  • Three optional basic courses have been activated:
    1. The cell (Prof. FOLLENZI Antonia)
    2. Basic genetics (Prof. GIORDANO Mara)
    3. Background of immunology (Prof. DIANZANI Umberto

    Attendance to these courses is highly suggested.

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