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Hematological applications

Course code:



Davide ROSSI



Degree program:

Course in Medical Biotechnologies









Comprehensive course:

Biotechnology of transplantation and Biocompatibility

Academic year:



Course objectives

The aims of the course are as follows:

  1. To know the biology of hematopoietic stem cell and of hemopoiesis
  2. To know the sources of hematopoietic stem cells, the biology of stem cell mobilization, and the procedures of processing hematopoietic stem cells
  3. To know the physiology of autologous, allogeneic and cord blood stem cell transplantation
  4. To know the pathogenesis of graft versus host disease
  5. To know the biotechnological procedures applied to hematopoietic stem cell transplantation (HLA typing, monitoring of engraftment and hematopoietic reconstitution, terapeutic manipulation and engineering of the graft)


Knowledge and skills expectations

Cell biology, immunology, molecular biology, pathology


Course program


Hematopoietic stem cell and hemopoiesis

  1. Hematopoietic stem cell biology
  2. Bone marrow microenvironment


Hematopoietic stem cells sources

  1. Bone marrow stem cells
  2. Peripheral blood stem cells
  3. Cord blood stem cells
  4. Stem cell mobilization and collection
  5. Stem cell processing and cryopreservation


Hematoietic stem cell transplantation

  1. Autologous hematopoietic stem cell transplantation
  2. Allogeneic hematopoietic stem cell transplantation
  3. Cord clod hematopoietic stem cell transplantation


Hematopoietic stem cell transplantation conditioning regimens

  1. Condistioning regimens for autologous hematopoietic stem cell transplantation
  2. Myeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation
  3. Non-myeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation


Cell Therapy

  1. Graft versus tumor reaction
  2. Therapeutic manipulations of the graft
  3. Therapeutic utilization of cellular populations


Practical training



Optional activities

Internship at the Laboratory of Hematology


Course materials

.ppt slide set


Required texbooks / Bibliographic resources

R. Hoffman, E.J. Benz, Jr., S.J. Shattil, B. Furie, H.J. Cohen, L.E. Silberstein, P. McGlave (editords). HEMATOLOGY. BASIC PRINCIPLES AND PRACTICE. 6th edition. Churchill Livingstone, New York, 2013


Methods of evaluation

Multichoice test

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