Skip to content. | Skip to navigation

University of Piemonte Orientale

Personal tools

You are here: Home / Courses / Molecular Diagnostics

Navigation

Molecular Diagnostics

Clinical Pathology
Course code:

BM047

Teacher:

Roberta ROLLA

SSD:

MED/05

Degree program:

Course in Medical Biotechnologies

Year:

II

Semester:

II

Credits

1

Hours

4

Comprehensive course:

Molecular diagnostics

Academic year:

2014/2015

 

Course objectives

This course provides an overview of the current knowledge in pharmacogenetics with functional importance for adverse drug reactions.

 

Knowledge and skills expectations

Thorough knowledge of Molecular Biology and Genetics (basics of genomics as well as methods to identify mutations).

 

Course program

The course provides the knowledge of genetic bases of variable drug response.

One of the great challenges in drug development and therapy is maximizing therapeutic response while avoiding adverse effects.

Advances in genetic knowledge, gained through sequencing, have identified heritable genetic variants that
predict drug response. Pharmacogenetics is the study of inherited genetic differences in drug metabolic
pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as
adverse effects/ toxicity.
The use of these genetic informations can play a major role in clinical practice to predict the right choice
and dose of medications for individuals, thus providing a scientific basic for “personalized medicine”. This is particularly important in the case of anticancer agents whose the therapeutic index is very narrow and a large proportion of patients do not respond.
Although the knowledge on an individual’s DNA sequence as an integral determinant of drug therapy has not yet become standard clinical practice, however several genetics recommendations/guidelines for physicians have been developed and are highlighted in the present course.

In particular, the course explores the pharmacogenetic clinical utility in:

 

  • antidepressant response
  • treatment of chronic pain
  • hormonal therapy with Tamoxifen (breast cancer)
  • hormonal therapy with aromatase inhibitors (breast cancer)
  • therapy with 5-Fluorouracil (colorectal cancer)
  • irinotecan treatment (colorectal cancer)
  • oral anticoagulant therapy
  • antiplatelet therapy

 

 

Practical training

Not provided

 

Optional activities

Not provided

 

Course materials

Powerpoint slides presentation

 

Methods of evaluation

Writing multiple choice questions

Notice

Notice for the students of the first year of Master in Medical Biotechnologies

  • Internship notice and form are available for download

  • Three optional basic courses have been activated:
    1. The cell (Prof. FOLLENZI Antonia)
    2. Basic genetics (Prof. GIORDANO Mara)
    3. Background of immunology (Prof. DIANZANI Umberto

    Attendance to these courses is highly suggested.

This is Schools Diazo Plone Theme